ImmunologybioRxivPreprint
Tumor-versus-non-tumor T cell enrichment supported by single-cell and spatial phenotyping enables antigen-agnostic prioritization of candidate tumor-reactive TCRs
Volkhard Seitz, Jannik Franzen, Kristin Gennermann…·Sefer Elezkurtaj
The paper identifies tumor-reactive TCRs using T/N ratios and validates them with single-cell and spatial data, showing their tumor association and effector phenotype.