Author

David DeBruin

Saint Louis UniversityORCID 0009-0009-7644-1367Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1 Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Michelle BrennaniD· 2 shared Anastasiia Vinogradskaia· 1 shared Anutosh ChakrabortyiD· 1 shared Christina Hadfield· 1 shared Cory GardneriD· 1 shared E C EbertiD· 1 shared Eshani KarmakariD· 1 shared Ethan R. NaquiniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersPathology

Michelle BrennanORCID

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3 papers

Recent·Most cited

PathologybioRxivPreprintJan 3, 2026

Loss of E3 ligase Ube4A disrupts colon homeostasis and accelerates experimental colitis via altered lipid handling

Simon Guignard, Molee Chakraborty, Silvia González-Nieves…·Vincenza Cifarelli

This study shows that loss of Ube4A in mice worsens experimental colitis by disrupting lipid metabolism and increasing inflammation.

DOI 10.64898/2026.01.02.697430

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 27, 2025

BDH1-Dependent Ketone Body Metabolism Maintains Muller Cell Homeostasis and Retinal Function

Richa Garg, Eshani Karmakar, David DeBruin…·Jaya P. Gnana‐Prakasam

This study shows that BDH1-dependent ketone metabolism supports Muller cell function and retinal health, with implications for treating retinal diseases.

1 citation

𝕏 PostBluesky

Evolutionary BiologybioRxivPreprintMar 17, 2024

Chromosome-level Subgenome-aware de novo Assembly of Saccharomyces bayanus Provides Insight into Genome Divergence after Hybridization

Cory Gardner, Junhao Chen, Christina Hadfield…·Tae-Hyuk Ahn

This study assembles the chromosome-level genome of Saccharomyces bayanus and compares it to its parental species to understand genome divergence after hybridization.

DOI 10.1101/2024.03.17.585453

yeastwhole-genome sequencing

𝕏 PostBluesky