Yan You

This study shows that Olig1/2 knockout in gliogenesis shifts glial precursor cells to produce non-proliferative interneurons instead of oligodendrocyte precursors, and identifies dorsal cortical GPCs as origin of H3.3G34R/V-mutant tumors.

This study uses scRNA-seq and snATAC-seq to show that radial glia sequentially generate neurons and glia through lineage progression, with chromatin accessibility regulating cell fate decisions.

This study identifies ERK-BMP7-GLI3R signaling in cortical radial glial cells as a driver of mammalian cerebral cortex expansion, with implications for evolutionary dwarfism in mice.