Guoping Liu

The paper shows that enhanced ERK signaling in human cortical radial glia drives cortical neuron expansion through interactions with PKA signaling and cell cycle regulation.

This study uses scRNA-seq and snATAC-seq to show that radial glia sequentially generate neurons and glia through lineage progression, with chromatin accessibility regulating cell fate decisions.

This study identifies ERK-BMP7-GLI3R signaling in cortical radial glial cells as a driver of mammalian cerebral cortex expansion, with implications for evolutionary dwarfism in mice.

The paper uses transcriptomic profiling and machine learning to identify 277 transcription factor networks involved in striatal neuron survival and their link to Huntington's disease.