Zhenmeiyu Li

Specialized Shh-sensing cell with unique cilia and basal body in the forebrain ventricular epithelium

The paper identifies a novel ependymal cell type (E2) in the forebrain that senses cerebrospinal fluid signals via specialized cilia and Smoothened receptor.

ERK signaling integrates multiple mechanisms to drive cortical evolutionary expansion

The paper shows that enhanced ERK signaling in human cortical radial glia drives cortical neuron expansion through interactions with PKA signaling and cell cycle regulation.

Progenitor Diversity and Architecture of the Human Ganglionic Eminences Shaping the Basal Ganglia

The paper identifies distinct progenitor populations in human ganglionic eminences, their gene regulatory networks, and lineage trajectories using single-nucleus transcriptomics and spatial transcriptomics.

Integrated ERK, PKA, YAP/TAZ, and SHH Signaling Drives Cortical Lineage Diversification and Evolutionary Expansion

This study identifies how ERK, PKA, YAP/TAZ, and SHH signaling integrate to drive cortical lineage diversification and evolutionary expansion in the human cerebral cortex.

Mouse Cortical Cellular Diversification Through Lineage Progression of Radial Glia

This study uses scRNA-seq and snATAC-seq to show that radial glia sequentially generate neurons and glia through lineage progression, with chromatin accessibility regulating cell fate decisions.

ERK signaling drives evolutionary expansion of the mammalian cerebral cortex

This study identifies ERK-BMP7-GLI3R signaling in cortical radial glial cells as a driver of mammalian cerebral cortex expansion, with implications for evolutionary dwarfism in mice.

Transcriptional Profiling Reveals the Transcription Factor Networks Regulating the Survival of Striatal Neurons

The paper uses transcriptomic profiling and machine learning to identify 277 transcription factor networks involved in striatal neuron survival and their link to Huntington's disease.