Thomas G. Oertner

The paper identifies that air bubbles in water bottles can cause dehydration in mice, and proposes a coiled wire solution to prevent this.

This study maps the development of prefrontal afferents from neonatal to adult stages, showing shifts in projection density and myelination patterns.

The paper investigates the molecular mechanisms of early and late long-term potentiation (LTP) by manipulating CaMKII activity and shows that L-LTP can occur without CaMKII activation.

The paper induces spike-timing-dependent plasticity in hippocampal synapses using optogenetics and performs ultrastructural analysis with transmission electron microscopy.

This paper introduces new organellar Ca2+ sensors with tunable colors and improved brightness and photostability for multiplexed measurements in different organelles.

The paper investigates how {Delta}FosB inhibition affects cFos expression and memory formation, finding that epigenetic repression of cFos supports sequential spatial memory formation.

The paper investigates the relationship between neuronal spiking frequency and FOS expression in hippocampal neurons, finding that FOS expression is cell-type specific, frequency-dependent, and not cell-autonomous.

The paper measures vesicular release probability at individual synapses and finds it determines synaptic strength rather than vesicle number or content.

The paper uses optogenetic stimulation to induce spike-timing-dependent plasticity (STDP) and shows that late potentiation occurs regardless of spiking order, but requires ongoing activity.

The paper demonstrates polarization sensitivity in GPCR-based neurotransmitter sensors and introduces an optical device to mitigate orientation bias in two-photon imaging.

This paper introduces TubuTag, a genetically encoded calcium sensor for imaging dendritic calcium signals in neurons with high temporal and spatial resolution.

This study shows that hyperpolarization of microglia membrane potential is essential for chemotaxis, while depolarization inhibits it.

The paper shows that endoplasmic reticulum (ER) visits active dendritic spines to prevent excessive synaptic potentiation.

The paper shows that cFos expression in the dentate gyrus changes daily and does not stabilize with spatial memory, yet neurons from early training days still influence later performance.

The paper introduces SynTagMA, a tool to mark active synapses in a 2-second window, and provides software for analyzing large datasets of synaptic activity.

This study identifies myosin V as essential for synaptopodin clustering at post-synaptic sites, showing that the spine apparatus is assembled locally rather than transported.

The paper shows that the sequence of plasticity-inducing events in hippocampal synapses affects their survival, with later protocols having a dominant effect.

The paper investigates the relationship between diffusional coupling in dendritic spines and long-term potentiation (LTP), finding that weakly isolated spines show significant LTP while highly isolated spines do not.

The paper develops ultrafast glutamate sensors iGluu and iGluf to study high-frequency synaptic transmission, revealing presynaptic frequency-dependent filtering of spike trains.

The paper engineers anion-conducting channelrhodopsins with tunable spectra and kinetics for optogenetic control of behavior.