Cell BiologyRSC Chemical BiologyPeer-reviewed
Tipping the balance: Synthesis and evaluation of centrinone-based degraders of polo-like kinase 4
Andrej Kovačević, Aleksandar Salim, Crisalida Borges…·Sascha Hoogendoorn
The paper develops and evaluates centrinone-based degraders of PLK4, finding that some lower PLK4 levels via degradation while others increase them by inhibiting autoregulation.