Sascha Hoogendoorn

Chemical Interrogation and Reprogramming of ATAT1-Mediated Tubulin Acetylation

This study develops chemical tools to measure, inhibit, and visualize ATAT1-mediated tubulin acetylation, enabling controlled manipulation of microtubule stability.

A biochemical probe for microtubule lattice integrity uncovers motor-caused lattice damage

This paper introduces MT-DS, a fluorescent probe that directly visualizes microtubule lattice damage, revealing motor-caused damage during motility.

Tipping the balance: Synthesis and evaluation of centrinone-based degraders of polo-like kinase 4

The paper develops and evaluates centrinone-based degraders of PLK4, finding that some lower PLK4 levels via degradation while others increase them by inhibiting autoregulation.

A comprehensive portrait of cilia and ciliopathies from a CRISPR-based screen for Hedgehog signaling

This study uses a CRISPR-based screen to identify genes critical for Hedgehog signaling and ciliary function, revealing novel components of ciliary structures and linking congenital heart defects to ciliopathies.