Patrick Meraldi

This study resolves a paradox in spindle length control by showing that coordinated regulation at both microtubule ends allows spindle length and poleward flux to vary independently.

The paper develops and evaluates centrinone-based degraders of PLK4, finding that some lower PLK4 levels via degradation while others increase them by inhibiting autoregulation.

This study shows that transient lagging chromosomes in anaphase, caused by loss of WDR62 and ASPM, lead to impaired cell proliferation and primary microcephaly through Aurora-B-dependent activation of 53BP1 and p21.