CCL3 promotes germinal center B cells sampling by follicular regulatory T cells.
Z. Benet, M. Marthi, R. Wu, J. S. Turner, J. B. Gabayre, M. I. Ivanitskiy, S. S. Sethi, I. L. Grigorova
Abstract
Previous studies and our findings suggest upregulated expression of proinflammatory chemokines CCL3/4 in germinal center (GC) centrocytes. However, the role of CCL3/4 for centrocyte interactions with follicular T cells and regulation of humoral immunity is poorly understood. We found that CCL3 promotes chemotaxis of Tfr cells ex vivo. In vivo CCL3 is not required for Tfr cells recruitment of into the GC light zone. However, B cells-intrinsic production of CCL3 promotes their direct interactions and negative regulation by follicular regulatory T cells (Tfr) within GCs.
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