Søren Egedal Degn

Thymic Treg-derived T follicular regulatory cells prevent catastrophic humoral autoimmunity in response to TLR7-driven inflammation

This study shows that thymic Treg-derived T follicular regulatory cells prevent autoimmunity by limiting GC responses during TLR7-driven inflammation.

Serial intravital microscopy reveals temporal dynamics of autoreactive germinal centers in the spleen

This study uses intravital microscopy to track autoreactive germinal centers in the spleen of live mice over weeks, revealing their dynamic expansion and contraction.

Display of clustered antigen by follicular dendritic cells tunes B-cell receptor activation

The paper shows that antigen clustering on follicular dendritic cells enhances B-cell receptor activation through geometric control of tyrosine phosphatase exclusion.

Multiparametric optimization of human primary B-cell cultures using Design of Experiments

This study optimizes human primary B-cell culture conditions using Design of Experiments, identifying CD40L and IL-4 as critical factors for viability and IgE class-switching.

AID facilitates TET2 demethylation of Irf4 for plasma cell fate in germinal center B cells

This study shows AID deficiency in B cells leads to reduced IRF4 expression and impaired plasma cell differentiation due to disrupted TET2-mediated demethylation of the Irf4 promoter.

LRP2 expression in melanoma is associated with a transitory cell state, increased T cell infiltration, and is upregulated by IFNγ signaling

This study identifies LRP2 expression in melanoma as linked to a transient differentiation state, T cell infiltration, and IFNγ signaling, with associations to better prognostic features.