Phylogenetic profiling identifies glucosyl-phosphoryl dolichol scramblase candidates

1. Background 1. Background 2. Results 3. Summary Appendix A:. List of... Appendix B:. Ranked top... References Protein glycosylation is essential for all eukaryotes, from disease-causing protists such as malaria and trypanosomes, to yeast and mammals. Secretory proteins are almost invariably N-glycosylated, O- and C-mannosylated, and/or GPI-anchored as they enter the lumen of the endoplasmic reticulum (ER).\n\nAll ER protein glycosylation reactions occur in the lumen and often involve lumenal mannosylation and glucosylation steps in which mannose and glucose residues are sourced from the glycolipids mannosyl- and glucosyl-phosphoryl dolichol (MPD and GPD, respectively) [1, 2]. Paradoxically, these two lipids are synthesized on the cytoplasmic ...