Author

A. K. Menon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 8 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 5 Organism:yeast· 4 Research Focus:cell type annotation· 3 Research Focus:protein folding & dynamics· 3 Assay:proteomics· 3 Approach:biophysical modeling· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

G. Khelashvili· 3 shared A. Jenni· 2 shared G. I. Dearden· 2 shared I. Menon· 2 shared J. Lee· 2 shared J. Levitz· 2 shared K. Pandey· 2 shared L. Bartos· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersBiochemistry

G. Khelashvili

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Author profile →

11 papers

Recent·Most cited

Molecular characterization of Rft1, an ER membrane protein associated with congenital disorder of glycosylation RFT1-CDG

E. Hirata, K.-t. Sakata, G. I. Dearden, F. Noor, I. Menon, G. N. Chiduza, A. K. Menon

This study characterizes the human Rft1 protein, showing it is an ER membrane protein essential for N-glycosylation, with mutations affecting its function in congenital disorders of glycosylation.

bioRxiv · Apr 3, 2024Cell Biology

A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors

I. Menon, T. Sych, Y. Son, T. Morizumi, J. Lee, O. P. Ernst, G. Khelashvili, E. Sezgin, J. Levitz, A. K. Menon

The paper shows cholesterol inhibits GPCR-mediated phospholipid scrambling in synthetic vesicles, suggesting a mechanism for maintaining plasma membrane asymmetry.

bioRxiv · Nov 24, 2023Biochemistry

Insertases Scramble Lipids: Molecular Simulations of MTCH2

L. Bartos, A. K. Menon, R. Vacha

The paper uses molecular simulations to show MTCH2 functions as a scramblase by reducing lipid transport barriers, similar to VDAC, suggesting insertases with hydrophilic paths may also act as scramblases.

bioRxiv · Aug 14, 2023Biophysics

Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase

H. Jahn, L. Bartos, G. I. Dearden, J. S. Dittman, J. C. M. Holthuis, R. Vacha, A. K. Menon

The paper identifies VDAC as a phospholipid scramblase that imports lipids into mitochondria through a mechanism distinct from its channel activity.

bioRxiv · Oct 17, 2022Biochemistry

A single vesicle fluorescence-bleaching assay for multi-parameter analysis of proteoliposomes by total internal reflection fluorescence microscopy

S. Veit, L. C. Paweletz, S. S.- R. Bohr, A. K. Menon, N. S. Hatzakis, T. Guenther Pomorski

The paper introduces a fluorescence-bleaching assay using total internal reflection fluorescence microscopy to analyze multiple parameters of proteoliposomes at the single-vesicle level.

bioRxiv · Apr 1, 2022Biochemistry

CLPTM1L is a lipid scramblase involved in glycosylphosphatidylinositol biosynthesis

Y. Wang, A. K. Menon, Y. Maki, Y.-S. Liu, Y. Iwasaki, M. Fujita, P. A. Guerrero, D. V. Silva, P. H. Seeberger, Y. Murakami, T. Kinoshita

The paper identifies CLPTM1L as a lipid scramblase essential for translocating glucosaminyl-phosphatidylinositol across the ER membrane during GPI biosynthesis.

bioRxiv · Jul 12, 2021 · PreprintBiochemistry

Endoplasmic reticulum phospholipid scramblase activity revealed after protein reconstitution into giant unilamellar vesicles containing a photostable lipid reporter

P. P. M. Mathiassen, A. K. Menon, T. Guenther Pomorski

The paper develops a fluorescence microscopy assay to measure scramblase activity in yeast ER proteins reconstituted into giant unilamellar vesicles using a photostable lipid reporter.

bioRxiv · Apr 1, 2021Biochemistry

Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in Trypanosoma brucei

A. Jenni, S. Knüsel, R. Nagar, M. Benninger, R. Häner, M. A. J. Ferguson, I. Roditi, A. K. Menon, P. Bütikofer

This study shows that eliminating GPI2 in Trypanosoma brucei reduces GPI GlcNAc transferase activity, alters GPI glycan modification, and affects social motility.

bioRxiv · Mar 18, 2021Biochemistry

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

G. Khelashvili, A. N. Pillai, J. Lee, K. Pandey, A. M. Payne, Z. Siegel, M. A. Cuendet, T. R. Lewis, V. Y. Arshavsky, J. Broichhagen, J. Levitz, A. K. Menon

The paper investigates the dimerization behavior of F220C rhodopsin mutant and wild-type opsin in vitro and in the plasma membrane, finding that the mutant forms a unique dimer with distinct conformational features.

bioRxiv · Dec 28, 2020Biophysics

Complexity of the eukaryotic dolichol-linked oligosaccharide scramblase suggested by activity correlation profiling mass spectrometry

A. Verchere, A. Cowton, A. Jenni, M. Rauch, R. Häner, J. Graumann, P. Bütikofer, A. K. Menon

This paper uses mass spectrometry-based activity correlation profiling to identify M5-DLO scramblase candidates in yeast but finds none are essential, suggesting regulation through quaternary structure.

bioRxiv · Apr 15, 2020 · PreprintBiochemistry

Water for sterol: an unusual mechanism of sterol egress from a StARkin domain

G. Khelashvili, K. Pandey, N. Chauhan, D. Eliezer, A. K. Menon

The paper reveals a water-controlled mechanism by which sterol exits the StARkin domain through a fracture, facilitated by hydration and polar residues.

bioRxiv · Apr 30, 2019Biochemistry