FabriEVEs: A dedicated platform for endogenous viral elements in fishes, amphibians, birds, reptiles and invertebrates

Abstract

Endogenous viral elements (EVEs) are heritable viral deriving elements present in the genomes of other species. As DNA fossils left by ancient viruses, EVEs were used to infer the characteristics of extinct viruses. EVEs in mammals have been well classified by several databases, however, EVEs in non-mammalian organisms are poorly documented. Here, we report FabriEVEs (http://tfbsbank.co.uk/FabriEVEs), the first dedicated and comprehensive online platform for the collection, classification and annotation of EVEs in fishes, amphibians, birds, reptiles and invertebrates. In total, nearly 1.5 million EVEs from 82 species deriving from class I (dsDNA), II (ssDNA), III (dsRNA), IV (positive ssRNA), V (negative ssRNA), VI (ssRNA-RT) and VII (dsDNA-RT) viruses were recorded in FabriEVEs, accompanying with comprehensive annotation including the species name, location, genomic features, virus family and associated literature. Flexible and powerful query options were provided to pinpoint desired EVEs. Furthermore, FabriEVEs provides free access to all EVEs data in case users need to download them for further analysis. Taken together, our database provided systematic classification and annotation of EVEs in non-mammal species, which paves the way for comparative analysis of EVEs and throws light upon the co-evolution of EVEs and their hosts.