Author

Daniel Blanco-Melo

University of WashingtonORCID 0000-0002-0256-5019Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:phylogenetics / evolution· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

María C. Ávila‐ArcosiD· 2 shared Alejandra CastilloiD· 1 shared Alejandro Meraz Moreno· 1 shared Anahí Sanchez Leon· 1 shared Anna GatsevaiD· 1 shared Axel A. Guzmán-SolísiD· 1 shared Benjamin Robert tenOeveriD· 1 shared Brad R. RosenbergiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersGenomics

María C. Ávila‐ArcosORCID

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Author profile →

4 papers

Recent·Most cited

Recovery of an 18th Century Rhinovirus Genome through Ancient RNA Isolation of Human Lungs

Erin Elizabeth Barnett, Alejandra Castillo, Isabelle A. Du Plessis, Kathryn E. Kistler, Laura Erika García Carrillo, Anahí Sanchez Leon, T Y Liu, Mike G. Rutherford, Jon Ploug, John T. McCrone, María C. Ávila‐Arcos, Daniel Blanco-Melo

This study recovers an 18th-century rhinovirus genome from ancient RNA isolated from human lung specimens, revealing insights into viral evolution.

bioRxiv · Jun 10, 2026 · PreprintGenomics

Pluripotency Factors Modulate Interferon Signaling in Embryonic Stem Cells

Qing Yang, Mónica Padilla-Gálvez, Skyler A. Uhl, Julie Eggenberger, Sophie Kogut, Sara Becker, Shuibing Chen, Brad R. Rosenberg, Daniel Blanco-Melo

This study shows that pluripotency factors in hESCs regulate negative interferon regulators, suppressing interferon signaling to maintain pluripotency while preserving antiviral resistance.

bioRxiv · Mar 27, 2026 · PreprintImmunology

A novel approach to exploring the dark genome and its application to mapping of the vertebrate virus 'fossil record'.

Daniel Blanco-Melo, Matthew A. Campbell, Henan Zhu, Tristan P. W. Dennis, Sejal Modha, Spyros Lytras, Joseph Hughes, Anna Gatseva, Robert James Gifford

The paper introduces a database-integrated genome screening approach to explore the dark genome, identifying over 1.1 million endogenous viral elements across 874 vertebrate species.

Genome biology · May 13, 2024Peer-reviewedGenomics

Ancient viral genomes reveal introduction of HBV and B19V into Mexico during the transatlantic slave trade.

Axel A. Guzmán-Solís, Daniel Blanco-Melo, Viridiana Villa-Islas, Miriam Bravo-Lopez, Marcela Sandoval‐Velasco, Julie K. Wesp, Jorge Gómez‐Valdés, María de la Luz Moreno-Cabrera, Alejandro Meraz Moreno, Gabriela Solís-Pichardo, Peter Schaaf, Benjamin Robert tenOever, María C. Ávila‐Arcos

This study reconstructs ancient viral genomes from Colonial-era remains in Mexico, linking their origin to Africa via the transatlantic slave trade.

eLife · Aug 5, 2021Peer-reviewedGenomics