bioRxivImmunologyPreprint
Human and murine neutrophils share core transcriptional programs in both homeostatic and inflamed contexts
N. S. Hackert, F. A. Radtke, T. Exner, H.-M. Lorenz, C. Mueller-Tidow, P. A. Nigrovic, G. Wabnitz, R. Grieshaber-Bouyer
Abstract
Neutrophils are frequently studied in murine models, but the extent to which findings translate to humans remains poorly defined. Here, we performed an integrative transcriptomic analysis of 11 murine and 13 human datasets. In homeostasis, neutrophils exhibited the highest number of lineage-specific genes and the greatest degree of correlated expression among genes with one-to-one orthologs (r = 0.79, P View larger version (17K): org.highwire.dtl.DTLVardef@1f6b40borg.highwire.dtl.DTLVardef@1a67bb4org.highwire.dtl.DTLVardef@1039a8forg.highwire.dtl.DTLVardef@1982d10_HPS_FORMAT_FIGEXP M_FIG C_FIG
- organism: human
- organism: mouse
- assay: bulk RNA-seq
- research focus: cell type annotation
- research focus: differential expression
- approach: statistical model
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