C. Mueller-Tidow

Multimodal and spatially resolved profiling identifies distinct patterns of T-cell infiltration in nodal B-cell lymphoma entities

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

Proteomic profiling identifies Serpin B9 as mediator of resistance to CAR T-cell and bispecific antibody treatment in B-cell lymphoma

Multiple myeloma long-term survivors display sustained immune alterations decades after first line therapy

This study examines immune changes in multiple myeloma survivors years after treatment, finding sustained immune alterations linked to residual disease and therapy.

Human and murine neutrophils share core transcriptional programs in both homeostatic and inflamed contexts

This study compares transcriptional programs of human and murine neutrophils in homeostasis and inflammation, finding shared core programs despite species differences.

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

CloneTracer identifies differentiation routes in AML by adding clonal resolution to single-cell RNA-seq data, revealing disease-defining compartments and therapy response mechanisms.

Pre-analytical processing of plasma and serum samples for combined proteome and metabolome analysis

This study evaluates pre-analytical factors affecting plasma and serum proteome and metabolome stability, recommending standardized protocols for clinical use.

Proteogenomics refines the molecular classification of chronic lymphocytic leukemia

The paper performs a proteogenomic analysis of chronic lymphocytic leukemia, identifies a new poor-prognosis subgroup (ASB-CLL) through proteomic profiling, and links it to clinical outcomes.

Comparing the value of mono- versus coculture for high-throughput compound screening in hematological malignancies

This study compares monoculture and stromal coculture for drug screening in hematological malignancies, finding that coculture reduces drug efficacy for many compounds but increases it for JAK inhibitors.

Aging and interferon gamma response drive the phenotype of neutrophils in the inflamed joint

This study identifies transcriptional and phenotypic changes in synovial fluid neutrophils from arthritis patients, highlighting IFNγ response and aging as key drivers.

Mutational synergy coordinately remodels chromatin accessibility, enhancer landscape and 3-Dimensional DNA topology to alter gene expression during leukemia induction

The paper investigates how mutations synergize to alter chromatin accessibility, enhancer landscapes, and 3D DNA topology in leukemia induction using a murine model.