X. Xie

Whole-genome resequencing revealed the Origin and Domestication of Chinese Domestic Rabbits

This study uses whole-genome resequencing to trace the origin and domestication of Chinese domestic rabbits, identifying genetic adaptations and multiple potential origins.

Targeting G9a translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae

This paper identifies G9a's role in SARS-CoV-2-induced pathogenesis by regulating translation of viral and host proteins, showing that G9a inhibitors can reverse disease-related proteomic changes.

IL-1beta-induced epithelial cell and fibroblast transdifferentiation fuels neutrophil recruitment in chronic rhinosinusitis with nasal polyps

This study identifies IL-1beta-induced cell subsets that promote neutrophil recruitment in CRSwNP and shows IL-1beta inhibition reduces inflammation.

Neutralizing gut-derived lipopolysaccharide as a novel therapeutic strategy for severe leptospirosis

This study identifies gut-derived lipopolysaccharide (LPS) as a therapeutic target in severe leptospirosis, showing that neutralizing LPS improves survival when combined with antibiotics or antibodies.

Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

This study shows vilazodone improves thrombocytopenia by activating SRC/MAPK signaling through 5-HT1A receptor in megakaryocyte differentiation.

Structure basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

This study determines the cryo-EM structure of QRFPR bound to 26RFa, revealing the recognition mechanism and aiding drug design for obesity and diabetes.

Engineering a genetic system for female-biased, genetically unmodified progeny in mice without affecting litter size

The paper describes a genetic system in mice that produces predominantly female offspring without affecting litter size or introducing genetic modifications into the offspring.

Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

This study identifies two double mutations in SARS-CoV-2 3CLpro that confer resistance to the non-covalent inhibitor WU-04 and reveals trade-offs between catalytic activity, thermostability, and drug resistance.

WTAP, transcriptionally regulated by p65, promotes inflammation through m6A modification and phase separation

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

Less neutralization evasion of SARS-CoV-2 BA.2.86 than XBB sublineages and CH.1.1

This study compares the neutralization evasion of SARS-CoV-2 variants BA.2.86, XBB sublineages, and CH.1.1, finding BA.2.86 less evasive than XBB sublineages but CH.1.1 most evasive.

Oxytocin alleviated colitis and colitis-associated colorectal tumorigenesis by targeting fucosylated MUC2

This study shows that oxytocin reduces colitis and CAC by enhancing MUC2 fucosylation via OXTR, suggesting it as a potential therapeutic for these conditions.

NUCLEOPORIN1 mediates proteasome-based degradation of ABI5 to regulate Arabidopsis seed germination

This study identifies NUP1's role in Arabidopsis seed germination by mediating proteasome-dependent degradation of ABI5.

Mecp2 Fine-tunes Quiescence Exit by Targeting Nuclear Receptors

This study shows Mecp2 negatively regulates quiescence exit by activating metabolic genes and repressing proliferation genes, with nuclear receptors Rara and Nr1h3 playing a key role.

Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy

This paper develops a method to rapidly prototype thermoplastic microfluidic devices for 3D cell culture by creating regional hydrophilicity discrepancies, enabling dynamic cell culture and drug screening.

Living cell mTORC1 inhibition reporter mTIR reveals nutrient-sensing targets of histone deacetylase inhibitor

The paper introduces a genetically encoded mTORC1 inhibition reporter, mTIR, which identifies histone deacetylase inhibitors that selectively target mTORC1 through nutrient-sensing gene expression.

A single-dose of intranasal vaccination with a live-attenuated SARS-CoV-2 vaccine candidate promotes protective mucosal and systemic immunity

S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness

This study shows that S:D614G and S:H655Y mutations enhance SARS-CoV-2 infectivity by stabilizing the Spike protein in an open RBD conformation, acting epistatically with the polybasic S1/S2 cleavage site.

Engineered symbiotic bacteria interfering Nosema redox system inhibit microsporidia parasitism in honeybees

The paper shows engineered symbiotic bacteria can inhibit microsporidia infection in honeybees by delivering RNAi targeting the parasite's redox system.

Humanized CD36 mouse model supports the preclinical evaluation of therapeutic candidates targeting CD36

This study creates a CD36 humanized mouse model to evaluate CD36-targeting therapies, showing that anti-CD36 antibodies inhibit tumor growth.

The ketone body acetoacetate activates human neutrophils through FFA2R

This study shows that acetoacetate activates human neutrophils via FFA2R, affecting cAMP levels, calcium signaling, ROS production, and migration.

Improved Neutralization of Omicron BA.4/5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent BA.4/5 Vaccine

This study compares the neutralizing antibody responses induced by monovalent and bivalent BA.4/5 vaccines against multiple Omicron sublineages in individuals over 55 years old, finding the bivalent vaccine elicits stronger neutralization.

Cross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages

This study examines the replication and cross-neutralization of SARS-CoV-2 Omicron sublineages in mice and human airway cultures, finding distinct antigenic profiles and bivalent vaccine support.

Aryl hydrocarbon receptor utilises cellular zinc signals to maintain the gut epithelial barrier

This study shows that AHR activation by dietary ligands improves gut barrier function via zinc-dependent pathways, highlighting the role of zinc in AHR signaling and its protective effects against IBD.

Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1, and XBB.1 by 4 doses of parental mRNA vaccine or a BA.5-bivalent booster

This study evaluates the neutralization effectiveness of parental mRNA vaccines and BA.5-bivalent boosters against new SARS-CoV-2 variants, showing limited neutralization against BA.2.75.2, BQ.1.1, and XBB.1.

Identification of a Prunus MAX1 Homolog as a Unique Strigol Synthase from Carlactone Bypassing 5-Deoxystrigol

The paper identifies a Prunus MAX1 homolog as a strigol synthase that bypasses 5-deoxystrigol synthesis, directly converting carlactone to strigol.

Data-Dependent Acquisition with Precursor Coisolation Improves Proteome Coverage and Measurement Throughput for Label-Free Single-Cell Proteomics

This paper introduces WWA, a data acquisition method that improves proteome coverage and throughput in single-cell proteomics by co-isolating and fragmenting additional precursors.

Determinants and Mechanisms of the Low Fusogenicity and Endosomal Entry of Omicron Subvariants

This study identifies mutations in the Omicron subvariant spike protein that reduce fusogenicity and increase endosomal entry, revealing mechanisms behind their immune evasion and pathogenesis.

Pangenome-based dynamic trajectories of intracellular gene transfers in Poaceae unveil a high rate of unceasing integration and selective retention in Triticeae

This study maps the dynamic trajectories of intracellular gene transfers in Poaceae using a novel tool, revealing lineage-specific patterns and functional roles of nuclear organelle genes.

Dual inhibition of SHP2 and autophagy suppresses NF1-associated Malignant Peripheral Nerve Sheath Tumors

This study shows that combining SHP2 and autophagy inhibition effectively suppresses NF1-associated MPNSTs in mouse models, suggesting a potential new treatment approach.

The RAM signaling pathway links morphology, thermotolerance, and CO2 tolerance in the global fungal pathogen Cryptococcus neoformans

This study identifies the RAM signaling pathway's role in CO2 and thermotolerance in Cryptococcus neoformans and discovers novel regulators of virulence.