Cryo-EM structure of the mechanically activated ion channel OSCA1.2
S. Jojoa Cruz, K. Saotome, S. E. Murthy, C. C. Tsui, M. S. P. Sansom, A. Patapoutian, A. B. Ward
Abstract
Introduction Introduction Main Author Contributions Expression constructs Protein expression and... Cryo-EM sample preparation and... Cryo-EM image processing Model building and refinement Molecular dynamics simulations Generation of mutant, cell... Electrophysiology Methods Data availability References Methods References Mechanically activated (MA) ion channels underlie touch, hearing, shear-stress sensing, and response to turgor pressure1,2. Previously reported as putative ion channels sensitive to osmolality3-5, members of ...
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