Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
R. Z. Hill, S. Shirvan, S. Burquez, A. E. Dubin, M. R. Servin Vences, J. H. Miner, A. Patapoutian
This study identifies PIEZO2 as a mechanotransducer in juxtaglomerular cells that regulates renin release and blood pressure.
bioRxiv · Nov 4, 2023 · PreprintPhysiology
A. R. Nickolls, G. S. O'Brien, S. Shnayder, Y. Zhang, M. Nagel, A. Patapoutian, A. T. Chesler
This study reevaluates Piezo1's role as a gut RNA sensor and finds that fecal ssRNA does not activate Piezo1, supporting its function in mechanosensation.
bioRxiv · Sep 23, 2022 · PreprintCell Biology
S. Jojoa-Cruz, K. Saotome, C. C. Tsui, W.-H. Lee, M. S. P. Sansom, S. E. Murthy, A. Patapoutian, A. B. Ward
This study characterizes the mechanosensitive ion channel FLYC1 using cryo-EM, MD simulations, and electrophysiology, revealing structural features and conformational transitions involved in mechano-gating.
bioRxiv · Jun 30, 2021Biochemistry
C. Procko, S. Murthy, W. T. Keenan, S. A. R. Mousavi, T. Dabi, A. Coombs, E. Procko, L. Baird, A. Patapoutian, J. Chory
The paper identifies a stretch-activated ion channel in touch-sensitive trigger hairs of carnivorous Droseraceae plants, suggesting it evolved from ancestral mechanosensitive channels.
bioRxiv · Dec 15, 2020Plant Biology
J. R. Holt, W.-Z. Zeng, E. L. Evans, S.-H. Woo, S. Ma, H. Abuwarda, M. Loud, A. Patapoutian, M. M. Pathak
This study shows that PIEZO1 channel localization dynamics regulate keratinocyte migration and wound healing speed in mice.
bioRxiv · Oct 18, 2020Biophysics
A. Patapoutian, S. A. R. Mousavi, A. E. Dubin, W.-Z. Zeng, A. M. Coombs, K. Do, D. A. Ghadiri, Y. Zhao, C. Ge
This study identifies PIEZO as a mechanosensitive ion channel in Arabidopsis roots, showing its role in mechanotransduction and mechanical stress response.
bioRxiv · Aug 27, 2020Plant Biology
S. Jojoa Cruz, K. Saotome, S. E. Murthy, C. C. Tsui, M. S. P. Sansom, A. Patapoutian, A. B. Ward
The paper presents the cryo-EM structure of the mechanically activated ion channel OSCA1.2 and supports its role in mechanosensation.
bioRxiv · Sep 4, 2018Biophysics
S. Murthy, A. Dubin, T. Whitwam, S. Jojoa Cruz, S. Cahalan, S. A. R. Mosavi, A. Ward, A. Patapoutian
The paper identifies OSCA proteins in plants and their homologues TMEM63 in animals as evolutionarily conserved mechanosensitive ion channels involved in mechanotransduction.
bioRxiv · Sep 4, 2018Biophysics
J. M. Kefauver, K. Saotome, A. E. Dubin, J. Pallesen, C. A. Cottrell, G. Hong, S. M. Cahalan, Z. Qiu, C. S. Crowley, T. Whitwam, W.-H. Lee, A. B. Ward, A. Patapoutian
The paper reports the high-resolution cryo-EM structure of human SWELL1, revealing its trimer of dimers assembly and identifying a charged residue critical for pore function in VRAC.
bioRxiv · May 16, 2018Biochemistry
S. Ma, S. Cahalan, R. Lohia, G. LaMonte, W. Zeng, S. Murthy, E. Paytas, N. D. Grubaugh, R. Gamini, L. Berry, V. Lukacs, T. Whitwam, M. Loud, A. I. Su, K. G. Andersen, , A. Patapoutian
The paper identifies a common Piezo1 variant in African populations that causes xerocytosis and reduces Plasmodium infection.
bioRxiv · Jul 6, 2017Physiology