Neurobiology of DiseaseGenomicsPeer-reviewed journal article
The Caribbean-Hispanic Alzheimer's Brain Transcriptome Reveals Ancestry-Specific Disease Mechanisms
Daniel FelskyiD, Ismael Santa‐MaríaiD, Mehmet İlyas CoşacakiD, Leon FrenchiD, Julie A. SchneideriD, David Alan BennettiD, Philip L. De JageriD, Çağhan KızıliD, Giuseppe TostoiD
Abstract
Ethnicity impacts Alzheimers disease risk, especially among Caribbean-Hispanics. We report the first RNA-sequencing analysis of brain tissue from 45 Alzheimers disease and control Caribbean-Hispanics. Data were compared with two independent samples of non-Hispanic Caucasians (total n=729). By identifying and characterizing those genes with ancestry- and region-specific expression patterns in Alzheimers disease, we reveal molecular insights that may help explain epidemiological disparities in this understudied aging population.
- organism: human
- assay: bulk RNA-seq
- research focus: differential expression
- research focus: gene regulatory network inference
- approach: statistical model
- approach: experimental assay
- Citations
- 25
- FWCI
- 2.94
- Field percentile
- top 8%
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