Mehmet İlyas Coşacak

This paper identifies APOE-ϵ4-induced fibronectin accumulation at the blood-brain barrier as a key mediator of astrocyte-endothelial dysfunction in Alzheimer's disease, highlighting it as a potential therapeutic target.

The paper compares regulatory changes in larval and adult zebrafish spinal progenitors after injury, showing they converge to a lesion-reactive state with distinct gene expression patterns.

The paper identifies an injury-induced stem cell-like state in zebrafish ERGs that promotes regenerative neurogenesis through lin28a and clcf1.

This study shows that sema4ab in microglia suppresses regenerative neurogenesis after spinal cord injury in zebrafish by altering microglia activation and fibroblast cytokine expression.

This study identifies ABCA7-dependent neuropeptide Y signaling as a resilience mechanism critical for synaptic integrity and its disruption as a risk factor for Alzheimer's disease.

This study identifies Foxj1's role in regulating olfactory cilia formation and OSN differentiation in zebrafish and mice.

The paper uses single-cell RNA sequencing to identify lateral floor plate progenitor cells as the origin of intraspinal serotonergic neurons in zebrafish.

The paper shows that Ngfr promotes neurogenesis and reduces amyloid pathology in AD mouse models by suppressing Lcn2/Slc22a17 signaling.

The paper analyzes RNA-seq data from Caribbean-Hispanic Alzheimer's patients and controls to identify ancestry-specific gene expression patterns associated with disease.

The paper uses GANs to generate synthetic cell nuclei and masks for training image segmentation models, demonstrating effectiveness with small datasets.

The paper characterizes motile ciliated cells in zebrafish brain ventricles, showing their developmental origins, functional roles in CSF flow, and impact on ventricular morphology.

This study shows that habenular neurons develop sequentially, with their functional properties determined by their birthdate during development.

The paper investigates glia-neuron interactions during seizure transitions in zebrafish, finding that glial activity precedes and influences neuronal activity during seizures.

The paper uses single-cell transcriptomics to analyze how Amyloid-beta42 and Interleukin-4 affect neural stem/progenitor cell plasticity in adult zebrafish brain, identifying gene expression changes and cell-cell communication alterations.

This study shows that IL4 restores neurogenic plasticity of human NSCs by suppressing KAT2, which is upregulated in AD mouse models.

The paper identifies two Jurkat subpopulations with distinct miRNA profiles during camptothecin-induced apoptosis, showing 6 miRNAs with inverse expression.

The paper examines small RNA distribution in Drosophila embryos during the maternal-to-zygotic transition, revealing fraction-specific enrichment and dysregulation of miRNAs and transposon-derived small RNAs.

This paper introduces a 3D hydrogel culture system to model human neural stem cell plasticity, neurogenesis, and neurodegeneration, showing improved neuronal maturation and disease modeling.