Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

Joana A. Revez; Tian Lin; Zhen Qiao; Angli Xue; Yan Holtz; Zhihong Zhu; Jian Zeng; Huanwei Wang; Julia Sidorenko; Kathryn E. Kemper; Anna A. E. Vinkhuyzen; Julanne Frater; Darryl Walter Eyles; Thomas H.J. Burne; Brittany L. Mitchell; Nicholas G. Martin; Gu Zhu; Peter M. Visscher; Jian Yang; Naomi R. Wray; John Joseph McGrath

doi:10.1038/s41467-020-15421-7

GeneticsNature CommunicationsApr 2, 2020

Peer-reviewed journal article

Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration.

Joana A. Revez iD, Tian Lin iD, Zhen Qiao iD, Angli Xue iD, Yan Holtz iD, Zhihong Zhu iD, Jian Zeng iD, Huanwei Wang iD, Julia Sidorenko iD, Kathryn E. Kemper iD, Anna A. E. Vinkhuyzen iD, Julanne Frater iD, Darryl Walter Eyles iD, Thomas H.J. Burne iD, Brittany L. Mitchell iD, Nicholas G. Martin iD, Gu Zhu iD, Peter M. Visscher iD, Jian Yang iD, Naomi R. Wray iD, John Joseph McGrath iD

Abstract

Vitamin D deficiency is a candidate risk factor for a range of adverse health outcomes. In a genome-wide association study of 25 hydroxyvitamin D (25OHD) concentration in 417,580 Europeans we identified 143 independent loci in 112 1-Mb regions providing new insights into the physiology of vitamin D and implicating genes involved in (a) lipid and lipoprotein metabolism, (b) dermal tissue properties, and (c) the sulphonation and glucuronidation of 25OHD. Mendelian randomization models found no robust evidence that 25OHD concentration had causal effects on candidate phenotypes (e.g. BMI, psychiatric disorders), but many phenotypes had (direct or indirect) causal effects on 25OHD concentration, clarifying the relationship between 25OHD status and health.

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