Corinne D. Engelman

This study identifies imidazole propionate as a gut bacterial metabolite linked to Alzheimer's disease pathology through human and mouse experiments.

COSIME integrates multi-omics data to predict Alzheimer's disease phenotypes, improving accuracy and interpretability by analyzing feature interactions across data views.

The paper identifies sex-specific genetic loci associated with memory, executive functioning, and language performance in older adults through genome-wide meta-analyses.

This study examines the association between APOE genotype and cognitive resilience in SuperAgers, finding lower APOE-ε4 and higher APOE-ε2 frequencies in non-Hispanic White SuperAgers compared to controls and Alzheimer's cases.

The paper identifies variance quantitative trait loci (vQTLs) for vitamin D levels and characterizes gene-environment interactions involving modifiable factors and sex.

The paper uses BADGERS to identify risk factors and endophenotypes for late-onset Alzheimer's disease by analyzing biobank-wide data.

The paper develops an APOE genetic risk score based on neuropathology that better explains CSF biomarker variance than traditional APOE ε4 metrics.

The paper performs a metabolome-wide association study to identify CSF metabolite-phenotype associations in neurological and psychiatric disorders.

The paper identifies seven metabolites associated with executive function decline in early Alzheimer’s disease using longitudinal plasma samples from the WRAP cohort.

The paper identifies CSF metabolites associated with tau levels and shows they improve prediction of Alzheimer's disease status.

This study identifies genetic variants and pathways associated with cognitive resilience to Alzheimer's disease, finding a novel locus linked to bile acid metabolism and methylation changes.

This paper investigates gene-environment interactions affecting vitamin D levels and optimal intake across different ethnic groups.

The paper develops ancestry-specific polygenic scores for 25(OH)D levels, showing they predict blood concentrations and inform vitamin D supplementation needs.

The paper integrates genomics, metabolomics, and Alzheimer’s risk factors from 1,111 participants to identify gene-metabolite-AD risk factor relationships and metabolites explaining tau variance.

This study identifies age and sex-associated metabolite trajectories in longitudinal plasma samples from the WRAP cohort, revealing sex-specific changes in metabolites like sphingolipids and heritability patterns.

The paper uses information-theoretic model-averaging to analyze cognitive decline factors in mid-life, finding sex, literacy, and APOE ɛ4 effects with varying impacts.

The paper reviews findings from the Wisconsin Registry for Alzheimer’s Prevention, highlighting associations between genetic and lifestyle factors and early AD pathophysiology.