Chemical CommunicationsBioengineeringPeer-reviewed journal article
Aptamer-based DNA nanoswitches for multiplexed protein detection
Sravya KovvaliiD, Camryn A. Beckles, Arun Richard ChandrasekaraniD, Ken HalvorseniD
Abstract
Simple, modular platforms for detecting biologically relevant proteins are critical for applications in clinical diagnostics, healthcare, and research. Here, we have combined aptamer-based protein recognition with our conformationally-responsive DNA nanoswitches to enable simple, sensitive and specific protein detection. We demonstrate dual detection of two clinically relevant blood proteins, thrombin and VEGF as initial proof of concept.
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