Arun Richard Chandrasekaran

This study shows that adding hairpins to DNA tetrahedra increases their nuclease resistance, enhancing biostability through sequence-specific stabilization.

This paper demonstrates the isothermal assembly of DNA nanostructures and 3D crystals in hydrated ionic liquids, enhancing biostability and enabling cell internalization without thermal annealing.

This work demonstrates the use of inosine in DNA nanostructures and shows its ability to form 3D DNA crystals through rationally designed motifs.

This paper demonstrates a method to encrypt hexadecimal data using PX DNA structures, which can be decrypted at specific temperatures and show stability and nuclease resistance.

The paper develops aptamer-based DNA nanoswitches for detecting proteins, demonstrating dual detection of thrombin and VEGF.

This paper demonstrates temperature and sequence-controlled reassociation of polycrossover DNA nanostructures into duplexes using anti-PX structures and formamide.

This study demonstrates the isothermal assembly of paranemic crossover DNA motifs in different counter ions at room and physiological temperatures and examines how design differences affect assembly of 4-stranded and 2-stranded molecules.

This study synthesizes and characterizes PNA/DNA hybrid three-way junctions and mesojunctions, showing improved thermal stability and nuclease resistance compared to DNA-only versions.

This study uses enhanced sampling to reveal how crossover points in PX/DNA structures enhance nuclease resistance by altering helix topology and reducing DNase I binding affinity.

This study shows that metal ions and temperature affect DNA nanostructure self-assembly, with divalent ions enabling assembly at lower temperatures and no adverse effects on cell viability.

This study investigates how base-stacking interactions affect the stability of DNA tetrahedra by testing 16 designs, finding that altering a single base stack can change melting temperatures by up to 10°C.

This study investigates DNA nanostructure assembly in various cations, showing successful assembly in Ca2+, Ba2+, Na+, K+, and Li+ with improved nuclease resistance in monovalent ions.

This study examines how the size of DNA tetrahedra affects their biostability, showing nuclease-specific degradation patterns.

This paper introduces a method using DNA nanoswitches to purify specific RNA species and validates its effectiveness with microRNA, rRNA, and mRNA fragments.