The reported healthy ageing gene expression score: lack of association in two cohorts
Luke C. PillingiD, Lorna W Harries, Dena G Hernandez, Andrew B Singleton, George A. KucheliD, Luigi FerrucciiD, David Melzer
Abstract
Sood et al. report a multi-tissue RNA signature \"predictive of human health, using only peripheral blood samples\". We tested this score in blood in two independent, larger cohorts and found no associations with age or related phenotypes, including muscle strength, interleukin-6 or mortality.
02 /Specification & Classification
Click any tag to browse matching papers- Organism
- Assay
- Research Focus
- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Inferring organ aging, hallmark of aging and senescence scores from blood and facial photographs
Kevin Schneider, Minja Belić, … David Furman·bioRxiv·Sep 29, 2026
- A proteomic signature of healthspan
Chia‐Ling Kuo, Peiran Liu, … Breno Satler Diniz·Proceedings of the National Academy of SciencesPeer-reviewed·Jun 6, 2025
- Transcriptome analysis reveals the difference between \"healthy\" and \"common\" aging and their connection with age-related diseases
Lu Zeng, Jialiang Yang, … Zhidong Tu·Aging CellPeer-reviewed·Feb 19, 2020
- Evidence of a pan-tissue decline in stemness during human aging
Gabriel Arantes dos Santos, Gustavo Daniel Vega Magdaleno, João Pedro de Magalhães·AgingPeer-reviewed·Apr 4, 2024
- Whole blood transcriptional signatures of age and survival identified in Long Life Family and Integrative Longevity Omics Studies
Mengze Li, Zeyuan Song, … Stefano Monti·GeroSciencePeer-reviewed·Feb 21, 2026
- Transcriptome features of striated muscle aging and predictability of protein level changes