Zeyuan Song

Pharmacogenomics of steroid-induced ocular hypertension: relationship to high-tension glaucomas and new pathophysiologic insight

The paper identifies 44 SNPs associated with steroid-induced ocular hypertension using a pharmacogenomic approach.

METABOLOMIC SIGNATURES OF EXTREME OLD AGE: FINDINGS FROM THE NEW ENGLAND CENTENARIAN STUDY

The paper identifies metabolomic signatures associated with extreme old age using data from the New England Centenarian Study and links them to biological age and mortality risk.

Whole blood transcriptional signatures of age and survival identified in Long Life Family and Integrative Longevity Omics Studies

This study identifies age and survival-related transcriptomic signatures in longevity-enriched cohorts using RNAseq data from blood samples.

Genetic Modifiers of Cognitive Function: Novel Genetic Associations with Memory, Executive Function, and Attention in the Long Life Family Study

This study identifies genetic variants associated with cognitive domains like memory and attention using GWAS in the Long Life Family Study, finding domain-specific genetic architecture.

Increased Genetic Protection Against Alzheimer's Disease in Centenarians

This study constructs a polygenic protective score for Alzheimer's disease and finds stronger genetic protection against AD in centenarians compared to non-longevity individuals.

Learning Gaussian Graphical Models from Correlated Data

This paper introduces a Bootstrap algorithm to infer Gaussian Graphical Models from correlated data, showing it controls Type I error better than conventional methods in simulations and a real family-based study.

yQTL Pipeline: a structured computational workflow for large scale quantitative trait loci discovery and downstream visualization

The paper introduces yQTL Pipeline, a tool for QTL discovery and visualization, applied to metabolomics data from NECS, identifying 14,983 mQTLs with improved efficiency.

Rare Genetic Variants Correlate with Better Processing Speed

A GWAS identified 20 rare genetic variants associated with better processing speed in the Long Life Family Study, replicated in Danish twin cohorts.

Distribution of 54 polygenic risk scores for common diseases in long lived individuals and their offspring

The paper evaluates 54 polygenic risk scores in long-lived individuals and their offspring, finding lower genetic risk for Alzheimer's, CAD, and lupus, but not for dementia in long-lived individuals.