Lu Zeng

Genetic insights into the association between inflammatory bowel disease and Alzheimer's disease

This study investigates the genetic overlap between inflammatory bowel disease and Alzheimer's disease, finding distinct myeloid cell-specific risk factors and some protective associations.

GWAS highlights the neuronal contribution to multiple sclerosis susceptibility

This study identifies 236 MS susceptibility variants and highlights neuronal and glial dysfunction as key factors in MS susceptibility.

Cell-subtype specific effects of genetic variation in the aging and Alzheimer cortex

The paper identifies cell-type and cell-subtype specific eQTLs in aging human cortex, revealing variant effects on gene expression and disease associations.

Transcriptomic changes highly similar to Alzheimer's disease are observed in a subpopulation of individuals during normal brain aging

The paper identifies transcriptomic changes in normal aging brains that resemble Alzheimer's disease in specific subgroups, suggesting early molecular links between aging and LOAD.

Tissue Specific Age Dependence of the Cell Receptors Involved in the SARS-CoV-2 Infection

This study analyzes the tissue-specific age dependence of cell receptors involved in SARS-CoV-2 infection and identifies key regulators and host processes hijacked by the virus.

A joint analysis of longevity and age-related disease variants for gene expression association

This study analyzes genetic variants associated with longevity and age-related diseases to understand their impact on gene expression.

Transcriptome analysis reveals the difference between \"healthy\" and \"common\" aging and their connection with age-related diseases

The paper compares gene regulations in 'healthy' and 'common' aging using GTEx data to identify differences and connections with age-related diseases.

The tuatara genome: insights into vertebrate evolutionfrom the sole survivor of an ancient reptilian order

The paper presents the tuatara genome, highlighting its evolutionary significance and unique features compared to other vertebrates.

Superior ab initio Identification, Annotation and Characterisation of TEs and Segmental Duplications from Genome Assemblies.

The paper introduces CARP, an ab initio pipeline for identifying and annotating TEs and segmental duplications in genome assemblies, showing it outperforms RepeatModeler.

Genome-Wide Analysis Of Repetitive Elements Associated With Gene Regulation

The paper analyzes the genome-wide impact of transposable elements on gene regulation, finding that Alu elements are associated with upregulated gene expression and contribute more to regulatory regions than ancient TEs.