Regional and Global Analysis of Cerebrovascular Reactivity Using 4D Flow MRI

Abstract

Cerebrovascular reactivity (CVR) assessments are promising for diagnostic and prognostic applications related to vascular function and neurodegenerative diseases. Current vascular imaging-based CVR indices have been limited to single-vessel analysis and report conflicting results, for example, whether there are differences in CVR between sexes. Alternative vascular imaging-based indices can be derived from 4D flow MRI, namely intracranial pulse wave velocity and pulsatility transmission, which are based on vascular regions and offer a more comprehensive perspective on vascular function that can also scale to a global level. To date, these types of indices have not been measured with a vascular stimulus. In this work, standard single-vessel and novel regional and global CVR indices were studied in 10 healthy young adults (29 {+/-} 2 years, 5 male, 5 female) in response to hypercapnia. Consistent increases in flow, area and velocity manifested at all levels and were greater in males. Regional pulse wave velocity and pulsatility transmission offered a minimum 40% increase in the dynamic range of CVR magnitudes that may benefit cohort stratification. Notably, pulse wave velocity increased in 50% of the vascular regions (most probably due to vasoconstriction), accompanying an increase in flow; a profound observation given the common expectation of vasorelaxation with hypercapnia. Consistently reduced flow, velocity, area, pulse wave velocity, and transmission index reactivities in females may partially explain the varying pathological outcomes between sexes, evidencing the continued value of 4D flow for the evaluation of CVR in other cohorts. New and NoteworthyCerebrovascular reactivity (CVR) of 4D flow-based intracranial pulse wave velocity and pulsatility transmission were evaluated during hypercapnia for the first time. Remarkably, pulse wave velocity increased in some cases and decreased in others, suggesting that vasorelaxation may not always occur during hypercapnia. These indices also expanded CVR dynamic range by more than 40 % compared to common velocimetry techniques, which could offer improved cohort stratification. Evidence of diminished CVR in females was also observed.