Yuguo Li

This study shows that restoring aquaporin-4 in a Huntington disease mouse model improves glymphatic function and reduces disease-related molecular and motor phenotypes.

This study shows that vascular smooth muscle cell loss, not amyloidosis or neuroinflammation, causes cerebrovascular reactivity impairment in Alzheimer's disease.

This study examines the spatiotemporal relationship between microstructural injury and cerebral perfusion after intracerebral hemorrhage in mice, finding dissociation between diffusion and perfusion responses.

The paper identifies microbleeds as a specific marker of amyloid-related vascular injury in 5xFAD mice, distinct from small-vessel disease.

This study characterizes hyperintense signals in pCASL MRI of mice, showing they appear in arteries, veins, and ventricles, differing from humans, and identifies optimal PLD and crusher gradient settings for accurate CBF measurement.

This study introduces a bidirectional crusher gradient method to estimate labeling efficiency in pCASL MRI for mice, finding typical efficiencies of 0.780 +/- 0.048.

This study examines vascular responses to hypercapnia in mice, showing that 5 minutes of 5% CO2 is sufficient for 95% CBF increase but recovery takes longer than the built-up phase.

This study uses MRI and fluorescence imaging to show impaired glymphatic function in a mouse model of Huntington disease, suggesting it as a potential biomarker and therapeutic target.