Zhiliang Wei

Reduced cerebral blood flow and metabolic rate trigger an adaptive mitochondrial remodeling program in a Down syndrome mouse model

In Dp16 Down syndrome mice, MRI shows reduced cerebral blood flow and oxygen metabolism (significant in males), while brain mitochondrial respiratory capacity stays largely intact and oxidative phosphorylation genes rise.

Vascular smooth muscle cell loss, but not neuroinflammation, drives cerebrovascular reactivity impairment in Alzheimer disease

This study shows that vascular smooth muscle cell loss, not amyloidosis or neuroinflammation, causes cerebrovascular reactivity impairment in Alzheimer's disease.

Dissociation of Diffusion and Perfusion Responses After Intracerebral Hemorrhage

This study examines the spatiotemporal relationship between microstructural injury and cerebral perfusion after intracerebral hemorrhage in mice, finding dissociation between diffusion and perfusion responses.

Vascular Microbleeds Without Brain Atrophy: A Microvascular Signature of Mid-Stage 5xFAD Pathology

The paper identifies microbleeds as a specific marker of amyloid-related vascular injury in 5xFAD mice, distinct from small-vessel disease.

Hyperintense signals in cerebral blood flow maps acquired with pseudo-continuous arterial spin labeling MRI in mice

This study characterizes hyperintense signals in pCASL MRI of mice, showing they appear in arteries, veins, and ventricles, differing from humans, and identifies optimal PLD and crusher gradient settings for accurate CBF measurement.

Magnetically Labeled iPSC-Derived Extracellular Vesicles Enable MRI/MPI-Guided Regenerative Therapy for Myocardial Infarction

This study develops magnetically labeled iPSC-derived extracellular vesicles for MRI/MPI-guided myocardial infarction therapy, showing improved cardiac function and detectability.

Bidirectional crusher gradient method for estimating the labeling efficiency of pseudo-continuous arterial spin labeling MRI in mice

This study introduces a bidirectional crusher gradient method to estimate labeling efficiency in pCASL MRI for mice, finding typical efficiencies of 0.780 +/- 0.048.

Progressively reduced cerebral oxygen metabolism and elevated plasma NfL levels in the zQ175DN mouse model of Huntington disease

This study characterizes the progression of the zQ175DN mouse model of Huntington disease, identifying early biomarkers like brain volume loss and plasma NfL elevation.

Cell type-specific contributions to impaired blood-brain barrier and cerebral metabolism in presymptomatic 5XFAD mice

The paper identifies cell type-specific transcriptomic changes in 5XFAD mice that link BBB dysfunction and metabolic dysregulation to early AD pathogenesis.

Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model

This study shows that senolytic therapy with D+Q preserves BBB integrity and improves cognitive function in a tauopathy mouse model.

Vascular responses of hypercapnia challenge in mice

This study examines vascular responses to hypercapnia in mice, showing that 5 minutes of 5% CO2 is sufficient for 95% CBF increase but recovery takes longer than the built-up phase.

Neural stem cells protect blood-brain barrier integrity via the p38, JNK, and ERK1/2 pathways following intracerebral hemorrhage in rats

This study shows that neural stem cells reduce BBB permeability and brain edema after ICH in rats by inhibiting MAPK pathways.

Interrogation of dynamic glucose-enhanced MRI and fluorescence-based imaging reveals a perturbed glymphatic network in Huntington disease

This study uses MRI and fluorescence imaging to show impaired glymphatic function in a mouse model of Huntington disease, suggesting it as a potential biomarker and therapeutic target.

HTT silencing delays onset and slows progression of Huntington disease like phenotype: Monitoring with a novel neurovascular biomarker

This study shows that HTT silencing in premanifest HD mice delays disease onset and slows progression, using CBVa as a noninvasive biomarker.

Deciphering the metabolic perturbation in hepatic alveolar echinococcosis: a 1H NMR-based metabolomics study

This study uses 1H NMR-based metabolomics to identify metabolic markers in HAE patients, revealing altered pathways and a lower Fischer ratio for early diagnosis.