bioRxivBioinformaticsPreprint
A bio-informatics approach to identify new drug targets in multidrug-resistant bacteria
Imogen RamsdeniD, Aryeh Chiam, Dominique HooglandiD, Martin B. UlmschneideriD
Abstract
Antibiotic resistance poses a global health crisis. In order to develop new antibiotic agents, it is crucial to identify drug targets in multidrug-resistant bacteria. Criteria for such a target are an -helical, essential membrane protein, that is non-homologues with the human membrane proteome, and present across multiple bacterial species. Using a stepwise subtractive genomics approach, the membrane protein F0F1 ATP synthase subunit C was identified as a non-human analogues drug target that is present in 11 bacterial species.
- organism: bacteria (other)
- assay: proteomics
- research focus: drug response / drug discovery
- approach: statistical model
- Citations
- 0
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