R. Shukla

Bridging fungal resistance and plant growth through constitutive overexpression of Thchit42 gene in Pelargonium graveolens

This study overexpresses the Thchit42 gene in Pelargonium graveolens to enhance fungal resistance and plant growth, showing increased leaf size and oil content.

A new antibiotic from an uncultured bacterium binds to an immutable target

This paper discovers a new antibiotic, clovibactin, from uncultured bacteria that targets pyrophosphate in bacterial cell wall precursors, effectively killing drug-resistant pathogens without resistance.

Chronic exposure of mice to phthalates enhances TGF beta signaling and promotes uterine fibrosis

This study shows that chronic exposure to a phthalate mixture in mice increases uterine fibrosis through enhanced TGF-beta signaling and collagen deposition.

A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance

This study identifies a novel antifolate, C1, that overcomes methotrexate resistance by targeting FPGS-deficient cells through DHFR inhibition.

In vitro and in vivo activity of Gepotidacin against drug-resistant mycobacterial infections

This study evaluates Gepotidacin's activity against drug-resistant mycobacteria, showing potent in vitro and in vivo efficacy, resistance bypass, and synergistic potential.

Ocimum sanctum, OscWRKY1, regulates phenylpropanoid pathway genes and promotes resistance to pathogen infection in Arabidopsis

This study identifies OscWRKY1 from Ocimum sanctum as a regulator of the phenylpropanoid pathway and pathogen resistance in Arabidopsis through direct binding to W-box cis-elements.

AtERF60, negatively regulates ABR1 to modulate basal resistance response in Arabidopsis

This study identifies AtERF60 as a regulator of ABR1, showing that AtERF60 overexpression enhances basal resistance to PstDC3000 while its mutation increases susceptibility.

Brevibacillin 2V, a novel antimicrobial lipopeptide with an exceptional low hemolytic activity

This study identifies and characterizes brevibacillin 2V, a novel antimicrobial lipopeptide with low hemolytic activity against eukaryotic cells, showing promise for antibiotic development.

Cocculus hirsutus -derived phytopharmaceutical drug has potent anti-dengue activity

This paper identifies Cocculus hirsutus-derived AQCH as a potent anti-dengue drug with in vitro and in vivo efficacy, characterized by five chemical markers and formulated into tablets for further development.

Rational Design of the Remdesivir Binding Site in the RNA-dependent RNA Polymerase of SARS-CoV-2: Implications for Potential Resistance

The paper designs mutations in the Remdesivir-binding site of SARS-CoV-2 nsp12 to predict resistance and identifies residues prone to mutation, suggesting EIDD-2801 may be more effective against resistance.

DNA methylation directs polycomb-dependent 3D genome re- organisation in naive pluripotency

This study shows that DNA hypomethylation in 2i conditions alters polycomb-mediated 3D genome organization in ESCs, but functional characteristics of 2i cells remain unchanged.