Mehdi Dehghan Manshadi

This study shows that combining ACLY and OGDH inhibitors VPA and BA synergistically inhibits HCC cell lines with minimal toxicity to normal liver cells.

This study identifies strictly-selective drug targets for 13 cancers using higher-order synthetic lethal sets to minimize harm to non-tumor tissues.

The paper systematically analyzes genome-scale metabolic models of six microorganisms to identify multi-target drug candidates that selectively target specific organisms.