A Hybridization-Based Novel DNA Storage Technology with Rapid Read Performance
Yifei Zhang, Lijia JiaiD, XiaoXia WANG, Yue ShiiD, Haihua Wang, Dongyi ZhangiD, Pengfei Cheng, Ye Zhao, Mingyuan Xu, Xinyi Zhang, Zuying Xiao, Lei WuiD, Xianghong Zhou, Di LiuiD
Abstract
The development of traditional silicon-based microelectronic storage media has increasingly lagged behind the rapidly growing demands of contemporary data storage. DNA storage, with its ultra-high information density and long-term preservation advantages, has rapidly become a research hotspot for next-generation storage technologies. However, current mainstream DNA storage methods based on synthesis and sequencing suffer from slow read/write speeds, hindering practical applications. To address this limitation, we propose an innovative hybridization-based DNA storage scheme. Through principle validation experiments, short-text read/write and error-correction tests, and high-density multi-format file storage experiments, we verify the feasibility of this approach. The proposed method exhibits high parallelism, rapid read speeds, and robust encryption capabilities, demonstrating promising application prospects in scenarios such as confidential data storage.
02 /Specification & Classification
Click any tag to browse matching papers- Citations
- 0
- Assay
- Approach
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Secure data storage on DNA hard drives
K. Chen, J. Zhu, … U. F. Keyser·bioRxiv·Nov 28, 2019
- PERFECT PCR: Advancing DNA Data Storage to Near-Maximal Density
Rushant Sabnis, Han Zhang, … Qing Sun·bioRxiv·Dec 18, 2025
- DNA Data Storage Architecture via Ligation of Dynamic DNA Bytes
Lijia Jia, Yue Shi, … Di Liu·Small MethodsPeer-reviewed·Mar 31, 2026
- Efficient DNA-based data storage using shortmer combinatorial encoding
Inbal Preuss, Michael Rosenberg, … Leon Anavy·Scientific ReportsPeer-reviewed·Apr 2, 2024
- Cost-effective DNA storage with DNA movable type
Chenyang Wang, Di Wei, … Fei Chen·Advanced SciencePeer-reviewed·Nov 18, 2024
- Engineering chimeric DNA polymerases for DNA movable type storage
Xutong Liu, Qixuan Zhao, … Quanshun Li·bioRxiv·Dec 19, 2025