Scientific ReportsGenomicsPeer-reviewed journal article
A comprehensive manually-curated Compendium of Bovine Transcription Factors
Marcela Maria de SouzaiD, Juan M. VaquerizasiD, Adhemar ZerlotiniiD, Ludwig GeistlingeriD, Benjamín Hernández-RodrígueziD, P. C. TiziotoiD, Jeremy F. TayloriD, Marina IP Rocha, Wellison J. S. DiniziD, Luiz Lehmann CoutinhoiD, Luciana Correia de Almeida RegitanoiD
Abstract
Transcription factors (TFs) are pivotal regulatory proteins that control gene expression in a context-dependent and tissue-specific manner. In contrast to human, where comprehensive curated TF collections exist, bovine TFs are only rudimentary recorded and characterized. In this article, we present a manually-curated compendium of 865 sequence-specific DNA-binding bovines TFs, which we analyzed for domain family distribution, evolutionary conservation, and tissue-specific expression. In addition, we provide a list of putative transcription cofactors derived from known interactions with the identified TFs. Since there is a general lack of knowledge concerning the regulation of gene expression in cattle, the curated list of TF should provide a basis for an improved comprehension of regulatory mechanisms that are specific to the species.
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