Richard A. Young

The paper investigates how active RNA synthesis influences nuclear condensate patterning by studying nucleolar fibrillar centers and shows that RNA synthesis affects their size, number, and spacing.

The paper identifies cis and trans gene regulatory mechanisms in microglia linked to multiple sclerosis risk SNPs using computational and CRISPR perturbation approaches.

This study introduces ProtGPS, a protein language model that predicts subcellular compartment localization and identifies mutations affecting this process.

The paper identifies RNA-binding as a common feature of transcription factors, showing it contributes to gene regulation and is conserved in vertebrates.

This study identifies a transcriptional mechanism that controls oligodendrocyte maturation through SOX6-mediated gene melting, showing that suppressing SOX6 accelerates maturation and that an immature SOX6 signature is enriched in multiple sclerosis patient brains.

The paper generates bat induced pluripotent stem cells and finds they contain endogenous viral sequences, suggesting a deep entanglement between bats and viruses.

This study identifies thyroid hormone receptor THRB as a key regulator of hepatocyte maturation from human PSCs, showing that T3 treatment enhances gene expression and epigenetic features of mature hepatocytes.

SARS-CoV-2 RNA can be reverse-transcribed by LINE-1 or HIV-1 reverse transcriptase, integrated into the human genome, and transcribed as chimeric viral-cellular RNAs.

This study shows that lncRNA DIGIT and BRD3 form phase-separated condensates to regulate endoderm differentiation by interacting with H3K18ac regions.

This study identifies enhancer features that drive transcriptional condensate formation through phase separation mechanisms involving TF binding site valency, density, and affinity.