Dorsolateral prefrontal cortex TMS evokes responses in the subgenual anterior cingulate cortex: Evidence from human intracranial EEG

Nicholas T. Trapp; Xianqing Liu; Zhuoran Li; Joel Bruss; Corey J. Keller; Aaron D. Boes; Jing Jiang

doi:10.1101/2024.12.20.629857

NeurosciencebioRxivDec 20, 2024

Preprint

Dorsolateral prefrontal cortex TMS evokes responses in the subgenual anterior cingulate cortex: Evidence from human intracranial EEG

Nicholas T. Trapp iD, Xianqing Liu iD, Zhuoran Li iD, Joel Bruss iD, Corey J. Keller iD, Aaron D. Boes iD, Jing Jiang iD

Abstract

Transcranial magnetic stimulation combined with intracranial local field potential recordings in humans (TMS-iEEG) represents a new method for investigating electrophysiologic effects of TMS with spatiotemporal precision. We applied TMS-iEEG to the dorsolateral prefrontal cortex (dlPFC) in two subjects and demonstrate evoked activity in the subgenual anterior cingulate cortex (sgACC). This study provides direct electrophysiologic evidence that dlPFC TMS, as targeted for depression treatment, can modulate brain activity in the sgACC.

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