Re-analysis of Transcriptomic and Proteomic Data Using Multi-Omics Approaches Identifies Biomarkers of Diabetes-Associated Complications in an INS Mutant Pig Model

Abstract

Mutant Insulin Induced Diabetes of Youth (MIDY) is an established porcine model caused by the INSC94Y mutation, which results in misfolded insulin, leading to severe {beta}-cell loss and hyperglycemia. Understanding disease pathophysiology is critical for identifying biomarkers and therapeutic targets, and animal models play a key role in this process. In this study, we re-analyzed published transcriptomic and proteomic data from the MIDY model using advanced multi-omics approaches and our in-house SurfacOmics tool. This integrative analysis identified ADAMTS17 as a novel biomarker, suggesting a potential association in diabetes-associated immune dysfunction and delayed wound healing through ECM-immune interplay.