Zoonotic spillover of SARS-CoV-2: mink-adapted virus in humans
L. Rabalski, M. Kosinski, N. Mazur-Panasiuk, B. Szewczyk, K. Bienkowska-Szewczyk, R. Kant, T. Sironen, K. Pyrc, M. Grzybek
Abstract
The COVID-19 pandemic caused by SARS-CoV-2 started in fall 2019. A range of different mammalian species, including farmed mink, have been confirmed as susceptible to infection with this virus. We report here the spillover of mink-adapted SARS-CoV-2 from farmed mink to humans after extensive adaptation that lasted at least 3 months. We found the presence of four mutations in the S gene (that gave rise to variant: G75V, M177T, Y453F and C1247F) and others in an isolate obtained from SARS-CoV-2 positive patient.
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