Identification of INSR protein structural differences in Diabetes Mellitus type 2 subjects from protein sequences

In this paper, we constructed several models of the Insulin Receptor protein(abbreviated INSR) from protein sequences from pathogenic and benign variants of type 2 Diabetes Mellitus patients. Through modeling these variants, we were able to determine which sections of the tertiary structure of the INSR protein were linked to type 2 Diabetes Mellitus. Ultimately, we created a map of the INSR protein and indicated which parts of the protein structure had significant effects on type 2 Diabetes Mellitus. We concluded differences in the charged/polar amino acids on the lower right section of the structure(amino acid numbers 487 and 750) were associated with pathogenic variants, while charged/polar differences on the lower left of the structure(amino acid numbers 669 and 784) had no impact on pathogenicity. We observed several differences in the amino acid chain structure, however they were not unique to the pathogenic variants; they were also seen in the benign variants.