Pascal Belleau

A versatile set of computational tools for inference of genetic ancestry from human molecular data

The paper introduces RAIDS, a toolset for inferring genetic ancestry from various sequence data, including cancer and low-coverage scenarios.

A High-Fidelity and Ancestrally Inclusive Patient-Derived Organoid Platform Resolves Cancer Cell Plasticity in Uterine Carcinosarcoma

This paper develops an ancestrally inclusive patient-derived organoid platform for UCS that captures cancer cell plasticity and identifies therapeutic vulnerabilities.

Comprehensive Molecular Characterization of High-Grade Endometrial Cancer in an Ancestrally-Diverse Cohort

This study characterizes the molecular differences in high-grade endometrial cancer across an ancestrally diverse cohort, identifying ancestry-associated mutations and immune microenvironment differences.

Accurate and robust inference of genetic ancestry from cancer-derived molecular data across genomic platforms

This study develops a data synthesis framework to accurately infer genetic ancestry from cancer-derived molecular data across genomic platforms, showing high accuracy across different sequencing depths and modalities.

A type 2 diabetes disease module with a high collective influence for Cdk2 and PTPLAD1 is localized in endosomes

The paper identifies a type 2 diabetes disease module in endosomes, highlighting Cdk2 and PTPLAD1 as key hubs with new genetic and functional associations.