Author

Gemma V. Brierley

Royal Veterinary CollegeORCID 0000-0002-4600-9970Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Antonio Vidal‐PuigiD· 1 shared Brian LamiD· 1 shared Constanze M. HammerleiD· 1 shared Corinne VigourouxiD· 1 shared Gema Medina‐GómeziD· 1 shared Grzegorz R. KudlaiD· 1 shared Hasan ÇubukiD· 1 shared Haydn M. ProsseriD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperDevelopmental Biology

Antonio Vidal‐PuigORCID

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2 papers

Recent·Most cited

Deep mutational scanning of the human insulin receptor ectodomain to inform precision therapy for insulin resistance

Vahid Aslanzadeh, Gemma V. Brierley, Rupa Kumar, Hasan Çubuk, Corinne Vigouroux, Kenneth A. Matreyek, Grzegorz R. Kudla, Robert K. Semple

The paper uses deep mutational scanning to assess the functional impact of INSR variants, identifying clinically relevant function scores and potential gain-of-function variants.

bioRxiv · Sep 7, 2024 · PreprintGenetics

Mesenchymal Igf2 is a major paracrine regulator of pancreatic growth and function

Constanze M. Hammerle, Ionel Sandovici, Gemma V. Brierley, Nicola M. Smith, Warren E. Zimmer, Ilona Zvetkova, Haydn M. Prosser, Yoichi Sekita, Brian Lam, Marcella K.L. Ma, Wendy N. Cooper, Antonio Vidal‐Puig, Susan Elizabeth Ozanne, Gema Medina‐Gómez, Miguel Constância

This study identifies mesenchymal Igf2 as a critical paracrine regulator of pancreatic growth and function through in vivo and ex vivo experiments.

PLoS Genetics · Oct 15, 2020Peer-reviewedDevelopmental Biology