bioRxivImmunology
SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo
K. Jakhar, S. Sonar, G. Singh, T. R. Asuru, G. Joshi, N. Beniwal, T. Sarkar, M. Tiwari, J. Kaur, D. K. Rathore, B. Lal, S. Kumar, P. Srivastav, S. Kumar, V. Phagna, S. Mithina, L. Kumar, V. Gupta, P. Kshetrapal, S. Singh, N. Wadhwa, R. Thiruvengadam, S. Raghavan, M. Gosain, T. Shrivastava, , S. Mani
Abstract
The presence of non-neutralizing antibodies of any dengue serotype, increase the severity of subsequent infection by other dengue serotypes. During SARS-CoV-2 pandemic, the number of symptomatic dengue cases increased in India. We describe that antibodies isolated from convalescent plasma from COVID-19 patients enhances DENV2 infection in vitro. CR3022, one antibody against SARS-CoV-2 spike protein, also showed elevated DENV2 infection in vitro. In silico protein-protein interactions between the spike antibodies and the DENV2 E-protein revealed significant interactions. Likewise, few monoclonal/polyclonal antibodies against SARS-CoV-2 showed increased dengue infection in vitro. Importantly, the AG129 mice infected with SARS-CoV-2 three-weeks prior to DENV2 infection, showed elevated dengue pathogenesis. Thus, highlighting the possibilities of elevated infection and symptomatic dengue disease in COVID-19 survivors.
- organism: mouse
- assay: proteomics
- research focus: host-pathogen & immune response
- research focus: cell-cell communication
- approach: experimental assay
- approach: statistical model
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