P. C. Wilson

Mutability and hypermutation antagonize immunoglobulin codon optimality

The paper examines how immunoglobulin codon optimality interacts with mutability and hypermutation in antibody evolution, finding that codon deoptimization correlates with expression loss and is constrained by selective pressures.

Germline-encoded specificities and the predictability of the B cell response

The paper investigates how germline alleles influence B cell responses to infection, showing that while they can lead to similar responses, diverse evolutionary paths limit genetic predictability.

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody to antigenically distinct omicron SARS-CoV-2 subvariants

This paper identifies a broadly neutralizing antibody against SARS-CoV-2 that targets the receptor-binding site and remains effective against multiple Omicron subvariants.

IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding

This study shows that IgG3 subclass antibodies neutralize antigenically drifted influenza and SARS-CoV-2 variants more effectively than other subclasses.

Librator, a platform for optimized sequence editing, design, and expression of influenza virus proteins

Librator is a platform for sequence editing and design of influenza virus proteins, enabling efficient mutation and chimeric protein creation for vaccine development.

An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines

This study identifies an egg-derived sulfated N-Acetyllactosamine glycan in influenza vaccines that acts as an antigenic decoy, inducing antibodies that may reduce immune response to protective epitopes.

A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

This study identifies a class of broadly neutralizing antibodies targeting a conserved membrane-proximal epitope on influenza HA, showing their induction by a chimeric HA vaccine.

Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus

The paper functionally and antigenically characterizes the hemagglutinin and neuraminidase of Wuhan spiny eel influenza virus to assess its status as a bona fide influenza virus.

SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike

This study finds that severe SARS-CoV-2 infection is associated with stronger antibody and memory B cell responses against the spike protein and nucleocapsid protein.

In situ humoral selection in human lupus tubulointerstitial inflammation

The paper shows that anti-vimentin antibodies in lupus nephritis undergo in situ selection for enhanced binding and specificity to vimentin fibrils, challenging the notion of affinity maturation as a non-specific consequence of polyreactivity.

Identification of antibodies targeting the H3N2 hemagglutinin receptor binding site following vaccination of humans

This study identifies H3N2 HA RBS-targeting antibodies in humans, showing some can be broadly reactive despite sensitivity to substitutions near the RBS.

Mapping person-to-person variation in viral mutations that escape polyclonal serum targeting influenza hemagglutinin

The paper maps how amino-acid mutations in influenza's hemagglutinin affect neutralization by polyclonal human sera, showing individual variation in escape mutations not observed in ferrets.

Hemagglutinin stalk-reactive antibodies interfere with influenza virus neuraminidase activity by steric hindrance

This study shows HA-stalk-reactive antibodies inhibit neuraminidase activity via steric hindrance, blocking viral egress and enhancing protection against influenza.