Author

J. J. Guthmiller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

L. Li· 4 shared M. Huang· 4 shared N.-Y. Zheng· 4 shared P. C. Wilson· 4 shared C. T. Stamper· 3 shared H. L. Dugan· 3 shared O. Stovicek· 3 shared S. Changrob· 3 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

L. Li

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Author profile →

5 papers

Recent·Most cited

Librator, a platform for optimized sequence editing, design, and expression of influenza virus proteins

L. Li, O. Stovicek, J. J. Guthmiller, S. Changrob, Y. Fu, H. L. Dugan, C. T. Stamper, N.-Y. Zheng, M. Huang, P. C. Wilson

Librator is a platform for sequence editing and design of influenza virus proteins, enabling efficient mutation and chimeric protein creation for vaccine development.

bioRxiv · Apr 29, 2021 · PreprintMicrobiology

An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccines

J. J. Guthmiller, H. A. Utset, C. Henry, L. Li, N.-Y. Zheng, W. Sun, M. C. Vieira, S. Zost, M. Huang, S. E. Hensley, S. Cobey, P. Palese, P. C. Wilson

This study identifies an egg-derived sulfated N-Acetyllactosamine glycan in influenza vaccines that acts as an antigenic decoy, inducing antibodies that may reduce immune response to protective epitopes.

bioRxiv · Mar 16, 2021Immunology

A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

J. J. Guthmiller, J. Han, H. A. Utset, L. Li, L. Y.-L. Lan, C. Henry, C. T. Stamper, O. Stovicek, L. Gentles, H. L. Dugan, N.-Y. Zheng, S. T. Richey, M. E. Tepora, D. J. Bitar, S. Changrob, , P. C. Wilson

This study identifies a class of broadly neutralizing antibodies targeting a conserved membrane-proximal epitope on influenza HA, showing their induction by a chimeric HA vaccine.

bioRxiv · Feb 25, 2021 · PreprintImmunology

SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike

J. J. Guthmiller, O. Stovicek, J. Wang, S. Changrob, L. Li, P. Halfmann, N.-Y. Zheng, H. Utset, C. T. Stamper, H. L. Dugan, W. D. Miller, M. Huang, Y.-N. Dai, C. A. Nelson, P. D. Hall, , P. C. Wilson

This study finds that severe SARS-CoV-2 infection is associated with stronger antibody and memory B cell responses against the spike protein and nucleocapsid protein.

bioRxiv · Sep 12, 2020Immunology

Biochemical Patterns of Antibody Polyreactivity Revealed Through a Bioinformatics-Based Analysis of CDR Loops

C. T. Boughter, M. T. Borowska, J. J. Guthmiller, A. Bendelac, P. Wilson, B. Roux, E. J. Adams

The paper identifies biochemical determinants of antibody polyreactivity using a bioinformatics pipeline and develops a classifier with over 75% accuracy.

bioRxiv · Jul 30, 2020Immunology