S. Mani

Type I interferon alters invasive extravillous trophoblast function.

This study shows that type I interferon reduces extravillous trophoblast invasion and induces a preeclampsia-like gene signature in an organ-on-a-chip model of implantation.

Extracellular vesicles alter trophoblast function in pregnancies complicated by COVID-19

This study shows that maternal extracellular vesicles from COVID-19 pregnancies alter trophoblast function, contributing to placental dysfunction.

Coordinated Immune Cell Networks in the Bone Marrow Microenvironment Define the Graft versus Leukemia Response with Adoptive Cellular Therapy

The paper analyzes single-cell data from bone marrow samples to identify immune cell interactions that predict response to adoptive cellular therapy in myeloid leukemia.

In Vitro Safety Signals for Potential Clinical Development of the Anti-Inflammatory Pregnane X Receptor Agonist FKK6

This paper performs in vitro pharmacological profiling of FKK6, showing high PXR selectivity, intestinal permeability, and rapid metabolism, supporting its potential preclinical development.

SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo

The paper shows that SARS-CoV-2 spike antibodies can enhance DENV2 infection in vitro and in vivo, suggesting potential for increased dengue severity in COVID-19 survivors.

Natural Product Screen Identifies Asiatic Acid Targeting Mutant p53

The paper screens natural compounds to identify Asiatic Acid as a potential inhibitor of the R248Q mutant p53, showing significant binding and interactions through molecular dynamics simulations.

Host inducible-HSP70A1A is an irresistible drug target to combat SARS-CoV-2 infection and pathogenesis

This study shows that inhibiting host Hsp70 reduces SARS-CoV-2 infection more effectively than Remdesivir by blocking viral entry and autophagy.

Human endogenous retrovirus-R envelope is a host restriction factor against severe acute respiratory syndrome-coronavirus-2

The paper identifies HERV-R envelope as a host restriction factor that inhibits SARS-CoV-2 replication through ERK and p38 MAPK signaling.

Gene Birth in a Model of Non-genic Adaptation

This study models the conditions under which non-genic loci can become functional, finding that strict conditions are required for successful functionalization.

Locus-specific enrichment analysis of 5-hydroxymethylcytosine reveals novel genes associated with breast carcinogenesis

This study identifies 4809 DMRs and 4841 DhMRs associated with breast cancer through locus-specific analysis of 5-hydroxymethylcytosine, revealing novel genes with pro-oncogenic roles.

Prophylactic treatment of Glycyrrhiza glabra mitigates COVID-19 pathology through inhibition of pro-inflammatory cytokines in the hamster model and NETosis.

This study shows that Glycyrrhiza glabra extract reduces inflammation and lung damage in hamsters infected with SARS-CoV-2 by lowering pro-inflammatory cytokines and NETosis.

Proinflammatory innate cytokines and metabolomic signatures shape the T cell response in active COVID-19

The paper examines how proinflammatory cytokines and metabolomic signatures influence T cell responses in active COVID-19 patients, showing preserved T cell responses against variants despite reduced antibody responses.

A combination of potently neutralizing monoclonal antibodies isolated from an Indian convalescent donor protects against the SARS-CoV-2 delta variant

This paper identifies two potent monoclonal antibodies from an Indian donor that neutralize SARS-CoV-2 variants including Delta, showing protection in a mouse model.

de novo gene birth as an inevitable consequence of adaptive evolution

The paper hypothesizes that de novo gene birth is driven by beneficial mutations in non-genic regions and shows this mechanism aligns with genomic observations.

Effect of prophylactic use of intra-nasal oil formulations in the hamster model of Covid-19

The paper evaluates two intra-nasal oil formulations in a hamster model of SARS-CoV-2 infection, finding that Anu oil reduces viral load, body weight loss, and lung pathology compared to the control.

Magnetic wire active microrheology of human respiratory mucus

This study uses magnetic wire microrheology to measure the viscoelastic properties of human respiratory mucus, finding a wide distribution of mucin network relaxation times and specific values for elastic modulus and viscosity.

Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

RNA-protein interaction analysis of SARS-CoV-2 5'- and 3'-untranslated regions identifies an antiviral role of lysosome-associated membrane protein-2

This study identifies host proteins interacting with SARS-CoV-2 5' and 3' UTRs, revealing Lamp2a's antiviral role by reducing viral RNA levels.

DIETARY MONOTERPENOIDS AS A NEW CLASS OF ALLOSTERIC HUMAN ARYL HYDROCARBON RECEPTOR ANTAGONISTS

The paper identifies carvones as non-competitive allosteric antagonists of the AhR, inhibiting target gene induction in a ligand-selective and cell type-specific manner.

Bacterial Swarmers exhibit a Protective Response to Intestinal Stress

This study identifies bacterial swarmers as protective against intestinal inflammation in mice and humans, showing their ability to enrich beneficial gut microbes.

Confinement Discerns Swarmers from Planktonic Bacteria

This study distinguishes swarming from planktonic bacterial motion by confining bacteria in microwells, revealing distinct motion patterns in swarming and planktonic states.

Design of a highly thermotolerant, immunogenic SARS-CoV-2 spike fragment

This paper designs a thermotolerant, immunogenic SARS-CoV-2 RBD protein fragment that is stable at high temperatures and elicits neutralizing antibodies in guinea pigs.

Interferons drive development of novel interleukin-15-responsive macrophages

This study identifies a novel IL-15-responsive macrophage population in the uterus driven by interferons, which may influence pregnancy outcomes.

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.

Optimizing a human fecal assay that elicits bacterial swarming

The paper develops and tests a fecal assay to assess bacterial swarming, finding that agar concentration and sample volume significantly affect swarming outcomes.

Inhibition of Microbial Beta-Glucuronidase Does Not Prevent Breast Carcinogenesis in the Polyoma Middle T Mouse

This study tests if inhibiting microbial beta-glucuronidase prevents breast cancer in MMTV-PyMT mice, finding no significant effect on tumor formation or markers.

Identification of lncRNAs associated with early stage breast cancer and their prognostic implications

This study identifies differentially expressed long non-coding RNAs in early-stage breast cancer and evaluates their prognostic significance using RNA sequencing and TCGA datasets.

RNA sequencing identifies dysregulated circular RNAs in early-stage breast cancer

This study identifies dysregulated circular RNAs in early-stage breast cancer using RNA sequencing and finds potential diagnostic and prognostic significance.