bioRxivNeurosciencePreprint
Cocaine withdrawal enhances subthalamic reward sensitivity
Maya Williams, Cassandre VielleiD, Jeanne-Laure de Peretti, Alix Tiran‐Cappello, Christophe MeloniD, Ali Awada, Yann PellouxiD, Nicolas MauriceiD, Christelle BauneziD, Mickaël DegouletiD
Abstract
High-frequency stimulation of the subthalamic nucleus (STN) has shown therapeutic potential in preclinical models of addiction. However, its rewarding properties remain unclear. Here, we show that cocaine withdrawal enhances STN intracranial self-stimulation, revealing a reward-based mechanism that may contribute to the beneficial effects of STN deep brain stimulation in addiction and related neuropsychiatric disorders.
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