Yann Pelloux

Subthalamic Nucleus Optogenetic Inhibition Bidirectionally Regulates Social Motivation According to Familiarity and Social Hierarchy

This study investigates how familiarity and social hierarchy influence social motivation in male and female rats, showing the subthalamic nucleus (STN) plays a role in regulating these behaviors.

Presence of an unfamiliar peer reverses escalated cocaine intake in male rats: involvement of the subthalamic nucleus

This study shows that the presence of an unfamiliar peer reduces cocaine intake in male rats, with the subthalamic nucleus mediating this effect during both short and long-access sessions.

Cocaine withdrawal enhances subthalamic reward sensitivity

This study shows that cocaine withdrawal increases reward sensitivity in the subthalamic nucleus, suggesting a potential mechanism for the therapeutic effects of deep brain stimulation in addiction.

Neural correlates in basolateral and central amygdala during reward seeking in the face of punishment

This study examines neural activity in the basolateral and central amygdala during reward seeking under punishment, finding that opposing neuronal populations in the CeA control reward-seeking behavior despite adverse consequences.

Peer presence and familiarity as key factors to reduce cocaine intake: an effect mediated by the Subthalamic Nucleus

This study shows that peer presence and unfamiliarity reduce cocaine intake in rats and humans, with the subthalamic nucleus mediating this effect.

Plasticity of the glutamate transporter EAAT2 on striatal astrocytes regulates flexibility inbehavior

This study shows that EAAT2 plasticity in striatal astrocytes affects behavioral flexibility, with overtraining leading to EAAT2 upregulation and impaired flexibility.

Low frequency oscillatory activity of the subthalamic nucleus is a predictive biomarker of compulsive-like cocaine seeking.

The paper identifies low frequency STN oscillations as a biomarker predicting compulsive-like cocaine seeking in rodents and shows DBS can modulate this behavior.

Subthalamic nucleus mediates the modulation on cocaine self-administration induced by ultrasonic vocalizations playback in rats

The paper investigates how ultrasonic vocalizations (USV) affect cocaine self-administration in rats and shows that subthalamic nucleus (STN) lesions block this effect.

A glimpse at deep brain stimulation mechanisms using subthalamic nucleus optogenetic manipulations

This study uses optogenetic manipulations in rats to investigate how subthalamic nucleus activity affects motivation for food and cocaine, revealing differences between optogenetic and electric deep brain stimulation effects.

Peer presence and familiarity as key factors to reduce cocaine intake: evidence from translational research

This study shows that peer presence and unfamiliarity reduce cocaine and stimulant intake in both rats and humans.